Known for his research in areas ranging from ketone ester, ketone salts and other ketone technologies, Dominic D’Agostino teaches at the University of South Florida’s Morsani College of Medicine and serves the Florida Institute for Human and Machine Cognition (IHMC) as a visiting research scientist. In his research, some of which is highlighted on the KetoNutrition website, Dominic D’Agostino has investigated the benefits of ketone supplementation and the ketogenic diet for a broad range of neurological diseases, cancer and to enhance safety and resilience in in the warfighter and astronaut.
The ketogenic diet involves the intake of foods high in fat very low in carbohydrates, and moderate in protein. Following a well formulated ketogenic diet typically results in significant body composition alterations, including rapid fat loss and sparing of muscle tissue. When accompanied with resistance training a modified ketogenic diet can effectively build muscle and strength. This approach works, in part, due to enhancing insulin sensitivity and preventing the development of insulin resistance that normally occurs with aging. Thus, the ketogenic diet is an effective means to enhance longevity.
When you eat carbohydrates, your body produces insulin. Greater levels of sustained insulin secretion result in decreased insulin receptor signaling, leading to insulin resistance and high levels of blood glucose. Persistent hyperglycemia trigger inflammation, nonalcoholic fatty liver disease and de novo lipogenesis. Ultimately your body then stores extra glucose as fat, causing weight gain, metabolic derangement, type 2 diabetes, and perhaps increasing the risk of cancer and other age-related chronic diseases.
Because a ketogenic diet reduces carbohydrate intake, it typically results in decreased insulin levels and an overall suppression of insulin signaling. Consequently, this accelerates fat mobilization and fat burning processes in the body and can help prevent or reverse the negative effects of insulin resistance.
With a PhD in neuroscience and physiology from the University of Medicine and Dentistry of New Jersey and Rutgers University, Dominic D’Agostino is now an associate professor at the University of South Florida Morsani College of Medicine. Dominic D’Agostino’s research is focused on areas such as nutritional ketosis, ketone supplementation and a wide range of metabolic-based therapies.
The ketogenic diet has become popular for its ability to help people lose weight and maintain muscle through supporting the body’s ability to remain in a state of nutritional ketosis. In ketosis, the body’s metabolic system gains its energy primarily from fatty acids, which the liver converts fast into molecules called ketones. Ketones also serve as powerful signaling molecules to boost antioxidant gene expression and reduce systemic inflammation.
Taking ketone supplements, often referred to as “exogenous ketones”, can play an important role in pursuing a optimizing your metabolic health. These supplements function in one of two ways: they augment energy levels for those already in ketosis, or they help push the body into nutritional ketosis. Ideally the ketone supplement (ketone salt) should be mixed with ketogenic fats, like medium chain triglycerides (MCT oil), which also stimulates endogenous ketogenesis.
Eating a ketogenic diet and taking supplements may not be enough to reach your goals, however. If you continue to gain weight, you may need to further decrease your carbohydrate intake to start ketosis, or you may need to decrease your overall calories (most important) to ensure you take in less than your body requires to maintain your current weight so that you can burn stored fat. Interestingly, things like nutritional ketosis, ketone supplementation and intermittent fasting make it easier for people to create a calorie deficit through appetite suppression effects.
Dominic D’Agostino earned his PhD in neuroscience and physiology from the University of Medicine and Dentistry of New Jersey, the medical school of Rutgers University. Now an associate professor at the University of South Florida, Dominic D’Agostino was recently featured in an article from Men’s Fitness about the effects of a ketogenic diet on metabolic health in humans.
Though the ketogenic diet is being praised for its tendency to help people burn fat, the health benefits of the strict eating regimen go far beyond weight loss. Among the diseases that a ketogenic diet may help control is epilepsy, a disorder in which the brain experiences sensory disturbances in sporadic episodes. The Epilepsy Foundation recommends the diet primarily for children with epilepsy that cannot be controlled through medication.
The results of several studies have shown that more than 50 percent of children with epilepsy who follow the ketogenic diet reduce the number of seizures that they experience by half, while another 10 to 15 percent cease to experience seizures completely. Dominic D’Agostino’s work has validated the use of nutritional ketosis for a wide range of disorders that are associated with seizures, including Glucose Transporter Type-1 Deficiency Syndrome and Angelmen’s syndrome.