Testing the Ketogenic Effects of KetoManna Chocolate Treats

Serving as assistant professor at the University of South Florida (USF), Dominic D’Agostino, PhD, focuses on ketone research and strategies of ketone supplementation and ketone technologies. Experienced in building muscle mass through ketone ester, Dominic D’Agostino, PhD, reviewed the keto chocolate KetoManna on his blog at ketonutrition.org.

With low-carb ketogenic diets requiring careful planning, a number of companies have created packaged foods that make adhering to the diet simpler. The ketogenic chocolate treat KetoManna is completely plant-based and contains 10 grams of medium chain triglcyerides (MCTs). Although MCTs are abundant in coconut oil and butter fat, pure MCT oils are not found in nature. They allow relatively high intake levels of carbs and proteins, while keeping the body in ketosis.

Maintaining a low-carb, non-keto diet, Dr. D’Agostino tested the effects of eating a packet of KetoManna through measuring blood ketone and blood glucose levels semi-fasted (before) and 45 minutes after ingestion. The results showed the product was ketogenic and kept both levels well within optimal ranges. His colleague, following a modified ketogenic diet, also had successful results.

In terms of taste, KetoManna was described as having a delicious nut butter texture. It can be hardened and eaten like a chocolate bar when refrigerated.


A Brief History of the Ketone Diet

Ketogenic Diet pic
Ketogenic Diet
Image: thetruthaboutcancer.com

Nutrition expert Dominic D’Agostino serves as an associate professor at the University of South Florida, where his work centers on metabolic therapies, including ketogenic diets, restricted diets, and exogenous ketogenic agents. As a result of his ketone research, Dominic D’Agostino regularly shares insights into the ketone diet with the media, including Men’s Health magazine and the Joe Rogan Experience podcast.

The ketone diet traces its roots to the 1920s, when Russel Wielder of the Mayo Clinic began to use the diet to treat epilepsy. Dietitians started recommending ketone supplementation in the 1970s, inspired by the ability of ketosis to efficiently burn fat.

In 1976, the Last Chance Diet used ketosis by instructing practitioners to drink a protein- and fat-rich mix until they’d lost the desired weight. The diet, devised by osteopath Robert Linn, stipulated a physician’s supervision, but it wound up causing heart complications that resulted in at least 60 deaths.

MIT-trained nutritional biochemist Stephen Phinney continued to work on the ketone diet, developing methods of delivering minerals that would protect against heart problems. Embracing ketone technologies, the Optifast diet emerged in the 1980s, and Oprah Winfrey’s support made it an immediate sensation.

Ketone research continued in the 1990s. Scientists and dietitians began to scale up ketone in 2013. The Gladstone Institute discovered that beta-hydroxybutyrate, a ketone body, activates anti-inflammatory genes and antioxidants, potentially slowing the aging process.

Today, the ketone diet’s potential to help people lose weight and reduce the signs of aging has turned ketone into an industry estimated at $5 billion. You can learn more about the emerging science and application of nutritional ketosis at Dr.Dom D’Agostino’s website KetoNutrition.org

Low-Carb Ketogenic Diet May Treat Breast Cancer, According to Studies

Ketogenic Diet pic
Ketogenic Diet
Image: thetruthaboutcancer.com

Dr. Dominic D’Agostino holds a PhD in neuroscience and physiology from the University of Medicine and Dentistry of New Jersey. Focusing on areas like ketone supplementation and ketone technologies, Dr. Dominic D’Agostino is currently an associate professor at the University of South Florida College of Medicine’s molecular pharmacology and physiology department. He is also a research scientist at the Institute for Human and Machine Cognition (IHMC).

Dr. Angela Poff, a research associate from the same department at USF, recently commented on studies to cover the science supporting the ketogenic diet as an adjuvant treatment for breast cancer. Dr. Poff discussed that since tumor cells rely primarily on glucose and glutamine, a low-carbohydrate diet keto diet may indeed deprive the cancer of its preferred source of fuel, also emphasizing the suppression of insulin signaling. She also emphasized, however, that further ketone research is needed to fully understand the cancer-suppressing characteristics of this diet. The preclinical work is compelling, but human clinical trials are needed.

The ketogenic diet is a low-carb diet that places the body under the metabolic state of nutritional ketosis. Carbohydrate restriction shifts the body’s metabolic physiology from a carbohydrate and glucose dependent metabolism to a fat and ketone-based metabolism. This process also suppresses may of the signaling factors that are driving the growth and proliferation of cancer.

According to studies, particularly one by Professor Thomas Seyfried of Boston College, the ketogenic diet may be capable of revolutionizing the treatment of breast cancer, even contending that cancer can be investigated as a metabolic disease rather than a genetic one. Evidence supporting the theory of cancer as a metabolic disease has major implication on how we treat and prevent cancer. It is likely that metabolic-based approaches will also synergize with other mof=dalities and further augment the cancer-killing effects of radiation, chemotherapy and newly evolving immune-based therapies.

How Vegans Can Follow a Ketogenic Diet


Ketogenic Diet pic
Ketogenic Diet
Image: theketogenicdiet.org

Associate professor at the University of South Florida’s Morsani College of Medicine, Dominic D’Agostino focuses his work on metabolic-based therapies, including ketogenic diets, and their potential for treating seizure disorders, muscle-wasting diseases, and other health problems. His lab oversees research on ketone technologies and ketone supplementation using ketone esters. Dominic D’Agostino’s work in the area of ketone research has also focused on following a vegan ketogenic diet.

The goal of someone on a ketogenic diet is to enter a state called ketosis, which occurs when the metabolism switches from burning glucose to burning ketones for fuel. In order to produce ketone bodies, a person must carefully manage their macronutrients so they are consuming much more fat than carbohydrates or protein. Although this can be a difficult task when following a plant-based diet, it certainly isn’t impossible.

A vegan or vegetarian interested in following a ketogenic diet must understand they will have to remove or severely limit their intake of fruit, grains, legumes, and some vegetables. They should replace these items with healthy plant-based fats, low-carb nuts and seeds, and low-carb vegetables such as broccoli, cauliflower, spinach, mushrooms, and cabbage.

It’s important for anyone wishing to reach and maintain ketosis to monitor what they’re eating to ensure 65 to 85 percent of their daily caloric intake comes from fat, 15 to 35 percent from protein, and 5 to 15 percent from carbohydrates. The exact nutrient ratio needed to adapt to ketone burning varies. Those who become “keto-adapted” report numerous benefits, including weight loss, increased energy and endurance, improved cognitive function, and reduced hunger.

Blood Sugar-Lowering Effects of a Novel Ketone Monoester Supplement


Dominic D'Agostino pic
Dominic D’Agostino
Image: ketonutrition.org

Dr. Dominic D’Agostino serves as an associate professor of molecular pharmacology and physiology at the University of South Florida in Tampa. In this position, Dr. Dominic D’Agostino studies the effects of ketone supplements.

A recent study published in the Journal of Physiology investigated the effects of a drink containing ketone esters on insulin control. Entering ketosis typically requires days on a strict diet–yet this drink proved to have similar results within minutes.

Participants in the study included 20 healthy males and females between the ages of 18 and 35. During the investigation, each participant fasted overnight and was then administered a standard oral glucose tolerance test upon waking to determine the effects of the drink on blood sugar and insulin levels.

Some of the participants were given a ketone supplement before the test, while a control group was administered a placebo. Participants who drank the ketone supplement not only showed a smaller resulting spike in their blood sugar levels, but also an improved insulin response. The study’s outcomes are promising since they suggest that ketone monoester supplements could have potential for managing and preventing metabolic disease.

See here for more information and podcasts on this topic: https://www.ketonutrition.org/

The Basis of a Vegetarian or Vegan Ketogenic Diet


Insulin Resistance Countered by the Ketogenic Diet


Dominic D'Agostinopic
Dominic D’Agostino
Image: ihmc.us

Known for his research in areas ranging from ketone ester, ketone salts and other ketone technologies, Dominic D’Agostino teaches at the University of South Florida’s Morsani College of Medicine and serves the Florida Institute for Human and Machine Cognition (IHMC) as a visiting research scientist. In his research, some of which is highlighted on the KetoNutrition website, Dominic D’Agostino has investigated the benefits of ketone supplementation and the ketogenic diet for a broad range of neurological diseases, cancer and to enhance safety and resilience in in the warfighter and astronaut.

The ketogenic diet involves the intake of foods high in fat very low in carbohydrates, and moderate in protein. Following a well formulated ketogenic diet typically results in significant body composition alterations, including rapid fat loss and sparing of muscle tissue. When accompanied with resistance training a modified ketogenic diet can effectively build muscle and strength. This approach works, in part, due to enhancing insulin sensitivity and preventing the development of insulin resistance that normally occurs with aging. Thus, the ketogenic diet is an effective means to enhance longevity.

When you eat carbohydrates, your body produces insulin. Greater levels of sustained insulin secretion result in decreased insulin receptor signaling, leading to insulin resistance and high levels of blood glucose. Persistent hyperglycemia trigger inflammation, nonalcoholic fatty liver disease and de novo lipogenesis. Ultimately your body then stores extra glucose as fat, causing weight gain, metabolic derangement, type 2 diabetes, and perhaps increasing the risk of cancer and other age-related chronic diseases.

Because a ketogenic diet reduces carbohydrate intake, it typically results in decreased insulin levels and an overall suppression of insulin signaling. Consequently, this accelerates fat mobilization and fat burning processes in the body and can help prevent or reverse the negative effects of insulin resistance.