Low-Carb Ketogenic Diet May Treat Breast Cancer, According to Studies

Ketogenic Diet pic
Ketogenic Diet
Image: thetruthaboutcancer.com

Dr. Dominic D’Agostino holds a PhD in neuroscience and physiology from the University of Medicine and Dentistry of New Jersey. Focusing on areas like ketone supplementation and ketone technologies, Dr. Dominic D’Agostino is currently an associate professor at the University of South Florida College of Medicine’s molecular pharmacology and physiology department. He is also a research scientist at the Institute for Human and Machine Cognition (IHMC).

Dr. Angela Poff, a research associate from the same department at USF, recently commented on studies to cover the science supporting the ketogenic diet as an adjuvant treatment for breast cancer. Dr. Poff discussed that since tumor cells rely primarily on glucose and glutamine, a low-carbohydrate diet keto diet may indeed deprive the cancer of its preferred source of fuel, also emphasizing the suppression of insulin signaling. She also emphasized, however, that further ketone research is needed to fully understand the cancer-suppressing characteristics of this diet. The preclinical work is compelling, but human clinical trials are needed.

The ketogenic diet is a low-carb diet that places the body under the metabolic state of nutritional ketosis. Carbohydrate restriction shifts the body’s metabolic physiology from a carbohydrate and glucose dependent metabolism to a fat and ketone-based metabolism. This process also suppresses may of the signaling factors that are driving the growth and proliferation of cancer.

According to studies, particularly one by Professor Thomas Seyfried of Boston College, the ketogenic diet may be capable of revolutionizing the treatment of breast cancer, even contending that cancer can be investigated as a metabolic disease rather than a genetic one. Evidence supporting the theory of cancer as a metabolic disease has major implication on how we treat and prevent cancer. It is likely that metabolic-based approaches will also synergize with other mof=dalities and further augment the cancer-killing effects of radiation, chemotherapy and newly evolving immune-based therapies.

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Keto Chocolate (KetoManna) Product Review

Following a ketogenic diet is not always easy, so it is pretty awesome that there are companies out there providing us with packaged foods that may make adhering to the diet a little less complicated, and likely more enjoyable.  The cool thing about the ketogenic diet is that you can easily see how something is affecting you by testing your blood glucose and blood ketone levels.  We love testing which foods and products keep us in ketosis so we can recommend the ones we ACTUALLY trust.

This time around, we tested out something extra delicious – KetoManna.  A ketogenic chocolate treat, with minimal ingredients, 10g of MCTs per serving, and is 100% plant-based! When warm, the texture is comparable to a nut butter, but can harden very quickly in the fridge/freezer and be eaten like a chocolate bar.     

This is an honest review we really do like KetoManna and any sales through our affiliate link go towards supporting our research   

Dr. Dom D’Agostino and myself tested our blood glucose and blood ketones, to give different perspectives, after consuming 1 packet (34g) of KetoManna.

DR. DOM’S RESULTS:

Context: Week of eating low carb (<75g carbohydrates/day), but not keto

Before (semi-fasted): 

Glucose: 3.5 mmol/L

Ketones: 1.0 mmol/L

Glucose Ketone Index: 3.5

45 minutes later: 

Glucose: 3.8 mmol/L

Ketones: 1.2 mmol/L

Glucose Ketone Index: 3.2

1.5 hour later: 

Glucose: 3.5 mmol/L

Ketones: 1.4 mmol/L

Glucose Ketone Index: 2.5

3 hours later: 

Glucose: 3.2 mmol/L

Ketones: 1.2 mmol/L

Glucose Ketone Index: 2.6

ketomanna-jarbox.jpg

KRISTI’S RESULTS:

Context: Following modified ketogenic diet (<40g carbohydrates/day)

Before (fasted): 

Glucose: 4.6 mmol/L

Ketones: 1.2 mmol/L

Glucose Ketone Index: 3.8

45 minutes later: 

Glucose: 5.0 mmol/L

Ketones: 1.8 mmol/L

Glucose Ketone Index: 2.7

2 hours later: 

Glucose: 4.5 mmol/L

Ketones: 1.2 mmol/L

Glucose Ketone Index: 3.7

Turns out KetoManna is well suited for a ketogenic diet.

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Besides being ketogenic, KetoManna tastes good… like really good.  It comes in individual packets (great for travelling), and depending on how creative you are, it can be used in a variety of ways. Rip the corner off and enjoy straight from the package, blend it into warm milk/nut milk for a keto hot chocolate, or let it harden in the fridge to be eaten like a chocolate bar (my personal favorite –>)

Use this link to support our research and enjoy a keto chocolate treat!

How Vegans Can Follow a Ketogenic Diet

 

Ketogenic Diet pic
Ketogenic Diet
Image: theketogenicdiet.org

Associate professor at the University of South Florida’s Morsani College of Medicine, Dominic D’Agostino focuses his work on metabolic-based therapies, including ketogenic diets, and their potential for treating seizure disorders, muscle-wasting diseases, and other health problems. His lab oversees research on ketone technologies and ketone supplementation using ketone esters. Dominic D’Agostino’s work in the area of ketone research has also focused on following a vegan ketogenic diet.

The goal of someone on a ketogenic diet is to enter a state called ketosis, which occurs when the metabolism switches from burning glucose to burning ketones for fuel. In order to produce ketone bodies, a person must carefully manage their macronutrients so they are consuming much more fat than carbohydrates or protein. Although this can be a difficult task when following a plant-based diet, it certainly isn’t impossible.

A vegan or vegetarian interested in following a ketogenic diet must understand they will have to remove or severely limit their intake of fruit, grains, legumes, and some vegetables. They should replace these items with healthy plant-based fats, low-carb nuts and seeds, and low-carb vegetables such as broccoli, cauliflower, spinach, mushrooms, and cabbage.

It’s important for anyone wishing to reach and maintain ketosis to monitor what they’re eating to ensure 65 to 85 percent of their daily caloric intake comes from fat, 15 to 35 percent from protein, and 5 to 15 percent from carbohydrates. The exact nutrient ratio needed to adapt to ketone burning varies. Those who become “keto-adapted” report numerous benefits, including weight loss, increased energy and endurance, improved cognitive function, and reduced hunger.

Blood Sugar-Lowering Effects of a Novel Ketone Monoester Supplement

 

Dominic D'Agostino pic
Dominic D’Agostino
Image: ketonutrition.org

Dr. Dominic D’Agostino serves as an associate professor of molecular pharmacology and physiology at the University of South Florida in Tampa. In this position, Dr. Dominic D’Agostino studies the effects of ketone supplements.

A recent study published in the Journal of Physiology investigated the effects of a drink containing ketone esters on insulin control. Entering ketosis typically requires days on a strict diet–yet this drink proved to have similar results within minutes.

Participants in the study included 20 healthy males and females between the ages of 18 and 35. During the investigation, each participant fasted overnight and was then administered a standard oral glucose tolerance test upon waking to determine the effects of the drink on blood sugar and insulin levels.

Some of the participants were given a ketone supplement before the test, while a control group was administered a placebo. Participants who drank the ketone supplement not only showed a smaller resulting spike in their blood sugar levels, but also an improved insulin response. The study’s outcomes are promising since they suggest that ketone monoester supplements could have potential for managing and preventing metabolic disease.

See here for more information and podcasts on this topic: https://www.ketonutrition.org/

The Basis of a Vegetarian or Vegan Ketogenic Diet

 

Insulin Resistance Countered by the Ketogenic Diet

 

Dominic D'Agostinopic
Dominic D’Agostino
Image: ihmc.us

Known for his research in areas ranging from ketone ester, ketone salts and other ketone technologies, Dominic D’Agostino teaches at the University of South Florida’s Morsani College of Medicine and serves the Florida Institute for Human and Machine Cognition (IHMC) as a visiting research scientist. In his research, some of which is highlighted on the KetoNutrition website, Dominic D’Agostino has investigated the benefits of ketone supplementation and the ketogenic diet for a broad range of neurological diseases, cancer and to enhance safety and resilience in in the warfighter and astronaut.

The ketogenic diet involves the intake of foods high in fat very low in carbohydrates, and moderate in protein. Following a well formulated ketogenic diet typically results in significant body composition alterations, including rapid fat loss and sparing of muscle tissue. When accompanied with resistance training a modified ketogenic diet can effectively build muscle and strength. This approach works, in part, due to enhancing insulin sensitivity and preventing the development of insulin resistance that normally occurs with aging. Thus, the ketogenic diet is an effective means to enhance longevity.

When you eat carbohydrates, your body produces insulin. Greater levels of sustained insulin secretion result in decreased insulin receptor signaling, leading to insulin resistance and high levels of blood glucose. Persistent hyperglycemia trigger inflammation, nonalcoholic fatty liver disease and de novo lipogenesis. Ultimately your body then stores extra glucose as fat, causing weight gain, metabolic derangement, type 2 diabetes, and perhaps increasing the risk of cancer and other age-related chronic diseases.

Because a ketogenic diet reduces carbohydrate intake, it typically results in decreased insulin levels and an overall suppression of insulin signaling. Consequently, this accelerates fat mobilization and fat burning processes in the body and can help prevent or reverse the negative effects of insulin resistance.

Using Ketone Supplements for Weight Loss

Dominic D'Agostino pic
Dominic D’Agostino
Image: ketonutrition.org

With a PhD in neuroscience and physiology from the University of Medicine and Dentistry of New Jersey and Rutgers University, Dominic D’Agostino is now an associate professor at the University of South Florida Morsani College of Medicine. Dominic D’Agostino’s research is focused on areas such as nutritional ketosis, ketone supplementation and a wide range of metabolic-based therapies.

The ketogenic diet has become popular for its ability to help people lose weight and maintain muscle through supporting the body’s ability to remain in a state of nutritional ketosis. In ketosis, the body’s metabolic system gains its energy primarily from fatty acids, which the liver converts fast into molecules called ketones. Ketones also serve as powerful signaling molecules to boost antioxidant gene expression and reduce systemic inflammation.

Taking ketone supplements, often referred to as “exogenous ketones”, can play an important role in pursuing a optimizing your metabolic health. These supplements function in one of two ways: they augment energy levels for those already in ketosis, or they help push the body into nutritional ketosis. Ideally the ketone supplement (ketone salt) should be mixed with ketogenic fats, like medium chain triglycerides (MCT oil), which also stimulates endogenous ketogenesis.

Eating a ketogenic diet and taking supplements may not be enough to reach your goals, however. If you continue to gain weight, you may need to further decrease your carbohydrate intake to start ketosis, or you may need to decrease your overall calories (most important) to ensure you take in less than your body requires to maintain your current weight so that you can burn stored fat. Interestingly, things like nutritional ketosis, ketone supplementation and intermittent fasting make it easier for people to create a calorie deficit through appetite suppression effects.